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05/13/2017

A novel immunotherapy to fight bladder cancer

Collaborating to move new treatments forward: Scientific rationale for the use of P-MAPA immunotherapy in the treatment of bladder cancer


A new drug to fight bladder cancer:

The experimental results of P-MAPA immunotherapy


                                                                                   


Based on experimental data and a scientific rationale, the research network Farmabrasilis announces P-MAPA  as an alternative to treat bladder cancer patients in five specific conditions that arise in the course of disease and treatements, and is looking for patient advocates, bladder cancer advocacy networks, research groups, institutions and pharmaceutical companies interested in establishing collaborations to move forward this novel therapy for bladder cancer.


P-MAPA has shown an impressive antitumor activity and a clear superiority over BCG, the standard treatment for bladder cancer, in comparative preclinical studies of efficacy and safety. As evidenced in animal models of bladder cancer, P-MAPA can help to overcome the BCGs lack of effectivity and toxicity. The toxicity of P-MAPA in the urothelium at therapeutic dosage is close to zero.


The Farmabrasilis Research Team argues that P-MAPA immunotherapy represents a novel approach to fight high-grade malignant lesions still in the urinary bladder, before they spread to adjacent tissues and organs. P-MAPA monotherapy could be used for treatment of non-invasive bladder cancer and also in association with other drugs for advanced forms of the disease, without additional toxicity.


The five conditions in which P-MAPA could be used, helping to solve unmet medical needs, are:


Condition 1: Patients with high-grade non-muscle invasive bladder cancer (NMIBC) at high risk of recurrence and disease progression who are BCG-refractory or BCG relapsing.


Condition 2: Patients with high-grade NMIBC at high risk of recurrence and disease progression who are BCG-intolerant.


Condition 3: Patients with high-grade NMIBC who are BCG-refractory or BCG relapsing, for whom cystectomy would be associated with high morbidity or mortality.


Condition 4: Patients with high-grade NMIBC, BCG-refractory and BCG-relapsing, at high risk of recurrence and progression, for whom cystectomy would be associated with high morbidity or mortality, and who are refractory to Valrubicin as second-line therapy.


Condition 5: Patients with locally advanced and metastatic bladder cancer.


See the full scientific rationale at:P-MAPA SCIENTIFIC RATIONALE 


Based on this scientific rationale, Farmabrasilis teams will be happy to discuss the possibilities of use of P-MAPA immunotherapy with patient advocates, bladder cancer advocacy networks, research groups, institutions and pharmaceutical companies interested in establishing collaborations to move forward this novel therapy for treatment of bladder cancer.


Our action can make the difference in the life of bladder cancer patients.


Send your questions, comments and/or proposal to:  

email

Please write P-MAPA in the subject line. You will receive a reply as soon as possible.


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