10/09/2008

2nd World Conference - Ehrlich II - Nürnberg - 2008 -Structure and Antimalarial Activity of Immunomodulator P-MAPA

Tasic L. et al- Structure and Antimalarial Activity of Immunomodulator P-MAPA ( Abstract 1216).  -

2^nd World Conference on Magic Bullets ( Ehrlich II ) - Nürberg 2008

Preview  :  The P-MAPA activity against malaria was evaluated in groups of 7-10 C57BL/6 female mice, 5-8 week-old and pathogen-free.

Upon infection with lethal cells of Plasmodium chabaudi AJ, P-MAPA was administrated in one, unique, dose of 100 mg/kg one day after infection, and in diary doses of 50 and 5 mg/kg/day - 1 h upon infection.

P-MAPA inhibited the parasitemia up to 100 % with only one dose of 100 mg/kg during six days of the infection, while the control survival was only 50 %.

With administration of 5 mg/kg per day, 90 % of animals survived during nine days, meanwhile 60 % of the control animals died.