04/08/2010

Tuberculosis references 01

 

Low-dose aerosol infection model

 

Kelly, B. P., S. K. Furney, M. T. Jessen, and I. M. Orme. 1996. Low-dose aerosol infection model for testing drugs for efficacy against Mycobacterium tuberculosis. Antimicrob Agents Chemother 40:2809-2812.

 

In vivo efficacy mouse models for M. tuberculosis

 

 

Currently, there are two animal models available for efficacy testing of compounds against M. tuberculosis; the Gamma Knock Out (GKO- IFN gamma knock out mice on a C57BL/6 background) model and a standard (C57BL/6 mouse) M. tuberculosis model. The GKO model allows a more rapid, initial assessment of drug efficacy in vivo. In the standard C57BL/6 mouse model, features as Minimal Effective Dose (MED), synergism with other compounds in drug combinations, sterilizing properties can be determined.

 

Source :

 

The Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF)